Contamination sensitive products and product components produced for the transportation, microelectronics (ICs, circuit boards, semiconductors), healthcare, pharmaceuticals, and medical devices industries require a standardized quality control to efficiently increase performance, reliability, and brand integrity. Particulate and molecular contaminants are one of the biggest challenges faced across various industries. Contaminants can be in the form of microscopic particulate matters and can pose various toxicological threats to the consumers. These contaminants often include inanimate or inorganic substances that can act as performance detractor for the products concerned. The investigation of contaminants requires the identification of particulate as well as molecular contaminants and the determination of various contamination sources is also required in the investigation. The objective of this process is to provide insights and to minimalize the impact of the contaminants on the product quality, efficacy and reliability. This step-by-step approach requires the collaboration of both the investigators and the client to understand the manufacturing process in-depth and to identify the potential root causes as well as to work on finding a remedy of the aforementioned problems to optimize the production, supply, and distribution chains specifically to avoid any of these issues. Validation techniques are incorporated that ascertain the level of cleanliness via the incorporation of a quantitative approach followed by optical or electron microscopic analysis to isolate the particles critical to the validation and a focused approach to solving the problem. Without optical or electron microscopy at the helm, it’s often difficult to isolate the particulate contamination problem that is prevalent in most industries and leads to difficulties in upholding the industrial quality standards without it.