Characterization of powder and optimization of processing methods.

“It is necessary that your powder processing methods are optimized and finely tuned to provide maximum outputs with superior standards, high dissolution capabilities, better flow properties, easier blending, improved stability and better bioavailability, whether they are ultimately converted into capsules, or used in the form of aerosol, or transformed into suspensions.”

Pharmaceutical Manufacturing Processes

Pharmaceutical manufacturing processes often involve the use of powders. Analysis and optimization of powder behaviour can help in formulating clinically effective products, developing time and cost-efficient processes and, ultimately, in successfully manufacturing a high-quality product consistently. This is particularly important as the physical properties of powder have an impact on processes like blending as well as capsule and tablet production. Effective powder characterisation is used by the pharma industry for providing core knowledge that creates better powder understanding and control. So, it is critical to have optimized powders.

The challenges

Many variables influence powder behaviour. Primary factors include particle size, shape, surface energy, morphology and roughness, but system variables will also have a profound impact. The degree of aeration and the level of moisture have a big role to play too. In many systems, the adjustments made by the R&D teams to achieve improved properties like enhanced delivery might impact the morphology of the powders. Furthermore, when it is scaled up for high volume production, it could lead to a non-uniform quality in the production system. This indicates that reproducible measurement and consistent processing depends on keeping a significant number of influential variables constant. Particle properties influence critical parts of product performance such as the dissolution rate, catalytic activity, or the surface finish delivered by an abrasive and hence characterisation and optimization is necessary.

Our solution for all your needs

The insights of our team of experts in the field of powder characterization can aid in alleviating the issues faced related to the morphology, flowability, product compatibility, selection of powder processing equipment and optimization of the powder. Our teams are experienced in formulation compatibility and powder assessment with the ability to characterize formulation performance during the primary stages of the development process to address problems pertaining to development.

Batch-to-batch variability and compromised yields are also relatively common in the manufacturing process, but our team’s rationalising experience can help you develop the understanding essential for a knowledge-led approach and to maximize the efficacy of all the involved processes. Our Comprehensive characterisation helps in understanding why certain powders behave in a specific way within a particular process and our experts help you to optimize powder properties and processing capabilities to implement superior quality control to maintain your standards. Our team of experts will help you launch the products more efficiently to keep your business growing.